BioGRID

What BioGRID is

BioGRID is a biomedical interaction database website at thebiogrid.org. It provides curated protein, genetic, chemical, complex, and post-translational modification interaction data compiled from biomedical literature and made searchable online.

Interaction records

The database is built around interaction records. A record may describe a physical protein interaction, a genetic interaction, a chemical interaction, or a post-translational modification relationship, depending on the source experiment and curation model.

Curation and evidence

BioGRID emphasizes curation from publications. That matters because interaction data is not just a list of pairs: users need organism, experimental system, publication, identifiers, qualifiers, and evidence context to understand what a relationship does and does not imply.

Search and networks

The website can be used to search for genes, proteins, organisms, publications, and interaction partners. Search results help users move from a single biological entity to a larger interaction neighborhood that can suggest pathways, complexes, functional links, or follow-up experiments.

Downloads and formats

BioGRID offers downloads in standardized formats, including tabular files documented by its wiki. Downloadable data is useful for reproducible analysis, local network construction, enrichment workflows, database integration, and teaching examples that need a citable release.

REST service

The BioGRID REST service supports programmatic queries. Developers and computational biologists can use it to retrieve interaction data, connect BioGRID to local software, build dashboards, or combine interaction records with resources such as Reactome, Gene Ontology, UniProt, and Ensembl.

Strengths and limits

BioGRID is powerful because it puts curated interaction evidence into a reusable database, but interaction networks require care. Literature coverage, experimental bias, indirect effects, organism differences, version changes, and edge-type differences can all affect how a network should be interpreted.

Why it matters

BioGRID matters because biological systems depend on relationships among genes, proteins, chemicals, and cellular processes. A public interaction database helps researchers move from isolated names to networks that can be searched, tested, downloaded, and connected to other biological knowledgebases.

WHOIS domain data

Data pulled: June 1, 2026 · View current WHOIS record

Domain

thebiogrid.org

IP address

104.21.6.151

Registrar

NameCheap, Inc.

WHOIS server

whois.namecheap.com

Referral URL

http://www.namecheap.com

Created

September 1, 2005

Updated

April 7, 2026

Expires

September 1, 2029

Nameservers

chase.ns.cloudflare.com (162.159.44.156); laylah.ns.cloudflare.com (162.159.38.230)

Domain status

clientTransferProhibited